Manufacturer/Distributor: Aristopharma Limited
Generic Name: Etoricoxib 120 mg Tablet
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Xibra is a pain relieving medicine. It is used for relieving moderate pain and swelling of joints associated with different forms of gout and arthritis. It is also used for short-term treatment of moderate pain after dental surgery in people 16 years of age and older. Xibra can be taken with or without food. The dose depends on what you are taking it for and how well it helps your symptoms. You should take it as advised by your doctor. Do not take more or use it for longer than recommended. The most common side effects of this medicine include stomach pain, edema, dizziness, headache, irregular heartbeat, and increased blood pressure. These are not usually serious but if you are worried, ask your doctor about ways of reducing or preventing them. Before taking it, you should let your doctor know if you have a history of ulcer or bleeding in your stomach, high blood pressure, or have any trouble with your heart, kidneys, or liver. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Pregnant or breastfeeding women should consult their doctor before starting treatment. You should also avoid drinking alcohol while you are taking this medicine. Heavy drinking can cause excessive drowsiness.
Uses of Xibra
Side effects of Xibra
Common
How to use Xibra
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Xibra may be taken with or without food, but it is better to take it at a fixed time.
How Xibra works
Xibra is a non-steroidal anti-inflammatory drug (NSAID) called COX-2 inhibitors. It works by blocking the release of certain chemical messengers that are responsible for pain and inflammation (redness and swelling).
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Brief Description
Indication
Rheumatoid arthritis, Osteoarthritis, Gout
Administration
May be taken with or without food.
Adult Dose
Oral Osteoarthritis Adult: 30 mg once daily, increased to 60 mg once daily if needed. Ankylosing spondylitis; Rheumatoid arthritis Adult: 90 mg once daily. Acute gout Adult: 120 mg once daily. Max duration: 8 days. Hepatic impairment: Mild (Child-Pugh score of 5-6): 60 mg once daily. Moderate (Child-Pugh 7-9): Max 60 mg every other day or 30 mg once daily. Severe (Child-Pugh >10): Avoid.
Child Dose
Child: <16 yr Contraindicated.
Contraindication
Inflammatory bowel disease, severe congestive heart failure, active peptic ulceration, cerebrovascular disease, CrCL <30 ml/min; lactation. Children and adolescent < 16 yr.
Mode of Action
Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor primarily responsible to reduce mediators of pain and inflammation. Its action is due to inhibition of prostaglandin synthesis via inhibition of COX-2.
Precaution
Allergic disorders, coagulation defects; history of cardiac failure, left ventricular dysfunction, hypertension, or in patients with oedema due to other reasons; elderly, renal, cardiac or hepatic impairment. Withdraw treatment if GI lesions develop; caution when admin to dehydrated patients. Regular BP monitoring is advisable. May mask fever and other signs of infection. Pregnancy.
Side Effect
GI disorders; ischemic cardiac events; hypersensitivity reactions, headache, dizziness, nervousness, depression, drowsiness, insomnia, vertigo, tinnitus, photosensitivity; blood disorders, fluid retention, hypertension; dry mouth, taste disturbance, mouth ulcers; appetite and wt changes; chest pain, fatigue, paraesthesia, influenza-like syndrome, myalgia. Renal toxicity.
Interaction
May increase INR w/ oral anticoagulants. May decrease effects of ACE inhibitors, angiotensin II antagonist and diuretics. May increase lithium plasma concentrations. May reduce plasma levels w/ rifampicin. Increased serum concentrations of ethinylestradiol.
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